Uses

This medication is used to prevent gout and gouty arthritis. It will not treat a sudden/severe attack of gout and may make it worse. Probenecid belongs to a class of drugs known as uricosurics. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. When uric acid levels get too high, crystals can form in the joints, causing gout. Lowering uric acid levels may also help your kidneys.

Probenecid may be prescribed in combination with certain antibiotics (such as penicillins). It increases the levels of antibiotic in the blood, which helps the antibiotic work better.

Probenecid should not be used by children younger than 2 years.

How To Use

To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. If you are on restricted fluid intake, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acidity in your urine (such as by avoiding large amounts of ascorbic acid/vitamin C) to prevent kidney stones. Your doctor may order other medications (such as sodium bicarbonate, citrate) to make your urine less acidic.

Dosage is based on your condition and response to therapy. Your doctor may direct you to take a low dose at first, then adjust your dose based on uric acid levels and your gout symptoms. After you have been symptom-free for several months and your uric acid levels are normal, your doctor may lower your probenecid dose to the lowest effective dose. Follow your doctor's directions carefully.

Probenecid should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication. You may experience an increase in the number of gout attacks for several months after starting this medicine while the body removes extra uric acid. If you have a gout attack while taking probenecid, continue taking it along with your medications for gout pain.

Probenecid is not a pain reliever. To relieve pain from gout, continue to take your medicines prescribed for pain from gout attacks (such as colchicine, ibuprofen, indomethacin) as directed by your doctor.

If you are taking this medication to raise the level of antibiotics in your body, follow your doctor's directions for when to take the antibiotic and when to take the probenecid.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Inform your doctor if your condition lasts or gets worse.

Side Effects

Nausea, loss of appetite, dizziness, vomiting, headache, sore gums, or frequent urination may occur as your body adjusts to the medicine. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur:

• lower back pain
• difficult/painful urination
• change in amount/color of urine

Tell your doctor right away if any of these rare but very serious side effects occur:

• easy bruising/bleeding
• signs of infection (such as fever, sore throat)
• severe abdominal pain
• pale stools
• unusual tiredness
• dark urine
• yellowing eyes/skin

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

• rash
• itching/swelling (especially of the face/tongue/throat)
• severe dizziness
• trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking probenecid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

• low blood counts (such as aplastic anemia, bone marrow depression)
• certain type of kidney stone (uric acid)

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

• cancer treatment
• a certain enzyme deficiency (G6PD)
• kidney problems (such as kidney stones, obstruction)
• peptic ulcer disease

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist that you are using this medication.

Kidney function declines as you grow older. This medication is removed by the kidneys. Elderly people may be at greater risk for side effects while using this drug, including stomach problems.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include:

• cancer chemotherapy
• baricitinib
• dyphylline
• ketorolac
• methotrexate
• pyrazinamide
• salicylates (such as high-dose aspirin)
• zidovudine
• certain drugs removed from your body by the kidneys (such as ceftazidime/avibactam, dapsone, heparin, fosfomycin)

Alcohol can decrease this drug's effectiveness. Limit alcohol while taking this medication.

This medication may interfere with certain laboratory tests (including urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 9-1-1. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe vomiting, loss of consciousness, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as uric acid blood levels, liver/kidney function tests, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

If you are using this medication to treat gout, your doctor may recommend a low-purine diet. Follow your doctor's instructions carefully.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.