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… severe pain, you may need stronger pain medicine, such as opioids. Medicine choices Medicines used to treat arthritis … antidepressants, such as duloxetine, to help relieve pain. Opioids to relieve severe pain. Medicine that you put on … Knee Pain Non-steroidal Anti-Inflammatory Drugs (NSAIDs) Opioids Surgery In most cases, people can manage their …

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